MTo

To, Kai-Tsun Michael

MBBS(HK), FRCS(Edin); FRCSE(Ortho)Edin; FHKCOS; FHKAM

Clinical Associate Professor

Division of Paediatric Orthopaedics
 

Research interests:

  • Nanomedicine in tissue regeneration – basic and clinical research in silver nanoparticles in enhancing collagen formation and spatial orientation of regenerated tissue
  • Design of drug delivering system for orthopaedic application using microfluidic system – PLGA-alginate core-shell microspheres with controlled size and homogeneous shells for drug delivery
  • Genetic study on type V osteogenesis imperfect – function of osteoblast in type V OI and the loss/gain of function of ITFM5 mutation
  • Genetic study on the development of congenital limb anomalies in Chinese  – genetic mutation in polydactyly

 

Clinical interest

  • Metabolic bone disease
  • Neuromuscular disease
  • Paediatric trauma
  • Congenital anomalies and bone dysplasia

 

Representative publications

  • Wu J, Kong T, Yeung K, Shum A, To M*. Fabrication and Characterization of Monodisperse PLGA-alginate Core-shell Microspheres with Monodisperse Size and Homogeneous Shells for Controlled Drug Release. Acta Biomaterialia. 2013 (In press).
  • Chow W, Negandhi R, Kuong E, To M*. Management pitfalls of fractured neck of femur in osteogenesis imperfecta. J Child Orthop. 2013 (In press).
  • Tiantian Kong, Jun Wu, Kelvin Wai Kwok Yeung, Michael Kai Tsun To*, Ho Cheung Shum, Liqiu Wang. Microfluidic fabrication of polymeric core-shell microspheres for controlled release applications. Biomicrofluidics. 2013. 7: 044128.
  • Kong T, Wu J, To M, Yeung K, Shum HC. Droplet based microfluidic fabrication of designer microparticles for encapsulation applications. Biomicrofluidics. 2012 (In press)
  • Kuong EE, To M, Yuen MH, Choi AK, Fong CM, Chow W. Pitfalls in diagnosing septic arthritis in Hong Kong children: ten years’ experience. HK Med J. 2012 Dec; 18(6):482-7.
  • To M.*, Negandhi R., Cheung K., Cheung W. Y., Chow W. 2012. Genitopatellar syndrome: a case report of a rare entity with 11 years of follow-up. Journal of pediatric orthopedics. Part B, 22, 333-8.
  • Hui PKT, Tung JYL, To MKT, Chow W, Lam WWM, Chau MT. Radiological features of osteogenesis imperfect type V: a report of two cases. HK J Radiol. 2012; 15:36-40.
  • To, M.*, Gupta, V., Chow W. 2011. Surgical management of long bone pseudarthrosis with severe limb length discrepancy in osteogenesis imperfecta. Journal of pediatric orthopedics. Part B, 22, 63-9.
  • Kwan K.H., Liu X, To M.*, Yeung K., HO C. M., Wong K. K. 2011. Modulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing. Nanomedicine : nanotechnology, biology, and medicine, 7, 497-504.
  • El-Fiky T, Chow W, Li YH, To M. Hereditary multiple exostoses of the hip. J Orthopaedic Surgery 2009; 17(2): 161-5.

 

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