LU, Weijia William

Ph.D, MHKIE

Professor emeritus

Professor Lu obtained his PhD degree and the “Distinguished Graduate Award” from the University of Waterloo, Canada, in 1994. He joined the Department of Orthopaedics & Traumatology, The University of Hong Kong (HKU) in 1995 as an Assistant Professor and was promoted to Associate Professor in 2001, and full Professor in 2009, and Ng Chun-Man Endowed Professorship in Orthopaedic Bioengineering (2013-2022). He established Orthopaedic Research Centre in 1995 and has served as director till 2022. Professor Lu has specific experience in the areas of Orthopaedic Biomechanics, Biomaterials, 3-D Bioprinting-technology as well as Clinical Bioengineering teaching and research. He has achieved substantial international recognition in the area of bioengineering and is widely acknowledged as top 1% scholars (2009-2018). Professor Lu has consistently secured a significant proportion of the research funding, including as chief scientist of the National Key R&D Programs, funded RMB27.44 millions in 2019 by the Ministry of Science and Technology (MoST). He held a number of patents for his innovations and has published more than 390 papers in international Peer Reviewed Journals, with H-index 77. Prof. Lu has spinoff three companies as co-founder with his PhD students, and he has supervised more than 60 Ph.D students.

• Biomechanics: Spinal Biomechanics, human tissue mechanical property evaluation and definition, Medical Implant biomechanical property evaluation;
• Biomaterials: Novel biomaterials development, bioactive bone cement fabrication and evaluations, Scaffold materials development, In vitro and in vivo biomaterials evaluation
• 3-D Bioprinting: To develop functionable human tissues and organs including full-thickness skin, cornea, bone, cartilage and major blood vessels etc.

• Degenerative Bone, Disc and Joints Research
• AI & Osteoporotic bone fractures

1. Li, F., Su, K., Riaz, F., Liu, C., Wei, P., Li, X., Zhang, K., Zhao, T., Xu, W., Zhao, X., Lu, W. W., Yang, Q., Zhao, L., Pan, F., & Pan, H. pH-neutralization strategy to suppress GPCR68 spatiotemporally activates T cells and enhances anti-tumor immunity. Bioactive Materials. 2026
2. Lin, J., Liu, Z., Fu, G., Zhang, H., Chen, C., Qi, H., Jiang, K., Zhang, C., Ma, C., Yang, K., Wang, C., Tan, B., Zhu, Q., Ding, Y., Li, C., Zheng, Q., Cai, D., & Lu, W. W. Distribution of bone voids in the thoracolumbar spine in Chinese adults with and without osteoporosis: A cross-sectional multi-center study based on 464 vertebrae [Article]. Bone. 2023
3. Jin Y, Zhang T, Lui YF, Sze KY, Lu WW*. The measured mechanical properties of osteoporotic trabecular bone decline with the increment of deformation volume during micro-indentation. J Mech Behav Biomed Mater. 2019
4. Kulper SA, Fang CX, Ren X, Guo M, Sze KY, Leung FKL, Lu WW. Development and initial validation of a novel smoothed-particle hydrodynamics-based simulation model of trabecular bone penetration by metallic implants. J Orthop Res. 2018
5. Chen Y, Hu Y, Yu YE, Zhang X, Watts T, Zhou B, Wang J, Wang T, Zhao W, Chiu KY, Leung FK, Cao X, Macaulay W, Nishiyama KK, Shane E, Lu WW*, Guo XE. Subchondral Trabecular Rod Loss and Plate Thickening in the Development of Osteoarthritis. Journal of Bone and Mineral Research. 2018
6. Zhai X, Ruan C, Ma Y, Cheng D, Wu M, Liu W, Zhao X, Pan H, Lu WW*. 3D-Bioprinted Osteoblast-Laden Nanocomposite Hydrogel Constructs with Induced Microenvironments Promote Cell Viability, Differentiation, and Osteogenesis both In Vitro and In Vivo. Adv Sci (Weinh). 2017
7. Gehua Zhen, Chunyi Wen, Simon Mear, Ting Wang, Frederic B Askin, Xiaofeng Jia, Franca Frassica, Weizhong Chang, Janet Crane, Jie Yao, Tariq Nayfeh, Dmitri Artemov, Andrew Cosgarea, John Corrino, Mei Wan, William Weijia Lu and Xu Cao. Inhibition of TGFβ1 Activity in Subchondral Bone Prevents Onset of Injury-Induced Osteoarthritis. Nature Medicine. 2013