• Mechanoresponsive skeletal tissue regeneration
• Crosstalk between bone and distal organs
• Skeletal stem cell for tissue regeneration

Dr. Sien Lin is an Assistant Professor in the Department of Orthopaedics and Traumatology, School of Clinical Medicine, LKS Faculty of Medicine of HKU. Dr. Lin obtained his PhD in the Chinese University of Hong Kong (CUHK) after attaining his medical degrees, then pursued his postdoctoral training in CUHK and Stanford University. After working as a Research Assistant Professor over 4 years in CUHK, Dr. Lin joined HKU in September 2025. Dr. Lin is passionate about the research and development (R & D) of regenerative strategies for challenging skeletal disorders. His recent work focuses on mechanoresponsive skeletal tissue regeneration, crosstalk between bone and distal organs, and skeletal stem cell for tissue regeneration. He has published over 100 publications in peer-reviewed journals including Nature Communications, Science Advances, Bone Research, Advanced Science, etc. His research is funded by the General Research Fund (GRF) of RGC Hong Kong, National Natural Science Foundation of China (NSFC), NSFC-RGC joint research scheme, Innovation and Technology Fund (ITF) and Heath and Medical Research Fund (HMRF). Dr. Lin serves as an editorial board member of Journal of Orthopaedic Translation (JCR Q1) and World Journal of Orthopedics. Dr. Lin also serves as a lifetime member of the International Chinese Musculoskeletal Research Society (ICMRS), Member of Association of Rehabilitation Medicine, and Tissue Engineering and Regenerative Medicine International Society (TERMIS). He was appointed as an adjunct professor of Orthopaedic Surgery in the Affiliated Hospital of Guangdong Medical University, China. Dr. Lin was a recipient of the TERMIS Student and Young Investigator Award, Best Poster awarded by ICMRS or ORS, and Bronze Medal of the Asia Exhibition of Innovations and Inventions. Dr. Lin serves as a grant reviewer for UK Research and Innovation (UKRI), British Medical Research Council (MRC), Dutch Research Council (NWO), and NSFC.  In addition, he also actively serves as a reviewer for over 20 journals.

• Wang H, Li Y, Li H, Yan X, Jiang Z, Feng L, Hu W, Fan Y, Lin S*, Li G*. T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration. Journal of Orthopaedic Translation, 2025; 51:82-93.
• Mi B, Xiong Y, Knoedler S, Alfertshofer M, Panayi A, Wang H, Lin S*, Li G*, Liu G. Ageing-related bone and immunity changes: Insights into the complex interplay between the skeleton and the immune system. Bone Research. 2024;12:42.
• Lin Y, Jiang Z, Yang J, Wang M, Zhang X, Lu X, Bai S, Wang H, Liang T, Li B, Shao J, Zhang L, Gao D, Chen J, Lin S*, Yang F*, Li G*. Development of a standardized and reproducible murine femoral distraction osteogenesis model. Journal of Orthopaedic Translation, 2024; 49:74-81.
• Lin S, Maekawa H, Moeinzadeh S, Lui E, Alizadeh HV, Li J, Kim S, Poland M, Gadomski BC, Easley JT, Young J, Gardner M, Mohler D, Maloney WJ, Yang YP. An osteoinductive and biodegradable intramedullary implant accelerates bone healing and mitigates complications of bone transport in male rats. Nature Communications. 2023;14(1):4455.
• Wang H^#, Lin S^#, Feng L, Huang B, Lu X, Yang Z, Jiang Z, Li YC, Zhang X, Wang M, Wang B, Kong L, Pan Q, Bai S, Li Y, Yang Y, Lee WYW, Currie PD, Lin C, Jiang Y, Chen J, Tortorella MD, Li H, Li G. Low-Dose Staphylococcal Enterotoxin C2 Mutant Maintains Bone Homeostasis via Regulating Crosstalk between Bone Formation and Host T-Cell Effector Immunity. Advanced Science. 2023;e2300989.
• Xie X, Li Z, Yang X, Yang B, Zong Z, Wang X, Duan L, Lin S*, Li G*, Bian L*. Biomimetic Nanofibrillar Hydrogel with Cell-Adaptable Network for Enhancing Cellular Mechanotransduction, Metabolic Energetics, and Bone Regeneration. Journal of American Chemical Society. 2023 Jul 19;145(28):15218-15229.
• Zong Z, Zhang X, Yang Z, Yuan W, Huang J, Lin W, Chen T, Yu J, Chen J, Cui L, Li G, Wei B, Lin S*. Rejuvenated aging mesenchymal stem cells by stepwise preconditioning ameliorates surgery-induced osteoarthritis in rabbits. Bone and Joint Research, 2021;10(1):10-21.
• Lin S, Cui L, Chen G, Huang J, Yang Y, Zou K, Lai Y, Wang X, Zou L, Wu T, Cheng JCY, Li G, Wei B, Lee WYW. PLGA/β-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model. Biomaterials. 2019;196:109-121.
• Lin S, Lee YW, Feng Q, Xu L, Wang B, Man CWG, Chen Y, Jiang X, Bian L, Cui L, Wei B, Li G. Synergistic Effects on Mesenchymal Stem Cell-based Cartilage Regeneration by Chondrogenic Preconditioning and Mechanical Stimulation. Stem Cell Research & Therapy. 2017;8(1):221.
• Lin S, Lee YW, Xu L, Wang Y, Chen Y, Ho KW, Qin L, Jiang X, Cui L, Li G. Stepwise Preconditioning Enhances Mesenchymal Stem Cell-based Cartilage Regeneration through Epigenetic Modification. Osteoarthritis Cartilage. 2017; 25(9):1541-1550.